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ICYMI: Highlights From ESMO Congress 2023
Our most-read coverage from the 2023 European Society for Medical Oncology (ESMO) Congress included potentially practice-changing findings across a range of cancer types, including lung cancer, breast cancer, and urothelial carcinoma.
Our most-read coverage from the 2023 European Society for Medical Oncology (ESMO) Congress included potentially practice-changing findings across a range of cancer types, including lung cancer, breast cancer, and urothelial carcinoma.
Here are the ESMO 2023 conference highlights. Click here to catch up on all of our coverage from the conference.
5. TROPION-Breast01, TROPION-Lung01 Demonstrate PFS Benefit of Datopotamab Deruxtecan in Metastatic Breast Cancer, NSCLC
Datopotamab deruxtecan demonstrated statistically significant and clinically meaningful improvements in progression-free survival (PFS) compared with standard of care in both non–small cell lung cancer (NSCLC) and hormone receptor–positive/HER2-negative breast cancer, according to findings presented at ESMO Congress 2023. In both presentations, trial investigators noted less toxicity with datopotamab deruxtecan compared with control interventions.
4. Dr Thomas Powles Discusses Impact of EV+P Therapy on Urothelial Carcinoma Treatment
Findings from the EV-302/KEYNOTE-A39 trial, presented at ESMO Congress 2023, suggest a new standard of care may be on the horizon in urothelial carcinoma for the first time in decades. Lead investigator Thomas Powles, MD, MBBS, MRCP, discussed the findings and the unmet need for therapies in metastatic urothelial carcinoma in an interview with The American Journal of Managed Care®.
3. Trastuzumab Deruxtecan Demonstrates Efficacy Reducing Brain Metastases in HER2m NSCLC
Results presented at ESMO Congress 2023 demonstrated that the presence of brain metastases (BM) did not affect response to treatment with trastuzumab deruxtecan among patients with metastatic HER2 (ERBB2)-mutant (HER2m) NSCLC. A significant proportion of patients with HER2m NSCLC have BM at diagnosis, and post hoc pooled analyses of trastuzumab deruxtecan efficacy and safety from DESTINY-Lung01 and DESTINY-Lung02 suggest similar response rates regardless of BM status.
2. Amivantamab Plus Lazertinib Improved PFS for EGFR-Mutated Advanced NSCLC
MARIPOSA and MARIPOSA-2 results showed improved PFS with amivantamab plus lazertinib vs osimertinib in the first-line setting and after progression on osimertinib in EGFR-mutated advanced NSCLC. In the MARIPOSA trial, the combination regimen reduced risk of progression or death by 30% vs osimertinib, and MARIPOSA-2 found that amivantamab plus chemotherapy and amivantamab plus chemotherapy and lazertinib also improved progression-free survival (PFS) over chemotherapy alone after progression on osimertinib.
1. First in Decades: Enfortumab Vedotin + Pembrolizumab Beats Chemo in First-Line Metastatic Urothelial Cancer
Enfortumab vedotin plus pembrolizumab significantly improved outcomes compared with standard-of-care chemotherapy in patients with locally advanced metastatic urothelial cancer, marking the first time in decades that a new treatment outperformed chemotherapy in this disease setting. Both PFS and overall survival were significantly prolonged in the enfortumab vedotin plus pembrolizumab, suggesting this regimen may be a new standard of care for advanced metastatic urothelial cancer.
NGS-Based Test Accurately Detects Post–Allo-HSCT Relapse in AML, MDS
February 21st 2025The next-generation sequencing (NGS)–based AlloHeme test accurately predicted relapse following allogeneic hematopoietic stem cell transplantation (allo-HSCT) in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS).
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The Importance of Examining and Preventing Atrial Fibrillation
August 29th 2023At this year’s American Society for Preventive Cardiology Congress on CVD Prevention, Emelia J. Benjamin, MD, ScM, delivered the Honorary Fellow Award Lecture, “The Imperative to Focus on the Prevention of Atrial Fibrillation,” as the recipient of this year’s Honorary Fellow of the American Society for Preventive Cardiology award.
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Promoting Equity in Public Health: Policy, Investment, and Community Engagement Solutions
June 28th 2022On this episode of Managed Care Cast, we speak with Georges C. Benjamin, MD, executive director of the American Public Health Association, on the core takeaways of his keynote session at AHIP 2022 on public health policy and other solutions to promote equitable health and well-being.
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“Expanding Access Isn’t Just About Fairness—It’s About Building Better Treatments for Everyone”
February 16th 2025Regina Barragan-Carrillo, MD, a postdoctoral fellow at City of Hope Comprehensive Cancer Center, discussed findings that show 76% of renal cell carcinoma trials take place in wealthy countries, amid news that clinical trial access for the world's poor may become even more challenging.
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Amid Debate Over Diversity, RCC Trials Still Struggle to Reflect Patient Populations
February 16th 2025Abstracts presented at the American Society of Clinical Oncology Genitourinary Cancers Symposium reflect the ongoing challenge with enrolling diverse patient populations in trials, despite stated goals.
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