• Center on Health Equity & Access
  • Clinical
  • Health Care Cost
  • Health Care Delivery
  • Insurance
  • Policy
  • Technology
  • Value-Based Care

How Does the Potential for Weight Gain Influence Choice of Therapies?

Video

Zachary T. Bloomgarden, MD, MACE: Weight gain is, of course, an important issue in diabetes. We know that diabetes occurs on a background of obesity in so many individuals. We know that the growth in obesity in the US population, and around the world, has tracked with the increase in the prevalence of diabetes. It’s unfortunate and upsetting that many of the drugs we use in treating diabetes actually are associated with weight gain—in particular, insulin, sulfonylureas, and thiazolidinediones.

So, as a first approximation, one would say we should try to avoid the use of these agents in people with diabetes whenever possible, recognizing that because diabetes is intrinsically a disease with reduced insulin secretory capacity, there are many individuals who simply will require insulin at some point in the natural history of their disease. Also, this new information from the IRIS (Insulin Resistance Intervention after Stroke) trial of pioglitazone recognizes that this may be an insulin sensitizer which reduces the possibility of stroke and myocardial infarction, and that could well outweigh any disadvantage of weight gain.


Related Videos
Andrew Kuykendall, MD, Moffitt Cancer Center
4 experts are featured in this series.
1 expert is featured in this series.
Anna Mueller, MD, Mount Sinai
Marc Humbert, MD, PhD
John Ostrominski, MD
John Buse, MD, PhD
Marc P. Bonaca, MD, MPH
Christian T. Ruff, MD, MPH
Related Content
© 2025 MJH Life Sciences
AJMC®
All rights reserved.