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Dr Stephen Heitner Outlines the Next Steps After MAVERICK-HCM Study Findings
Based off the rich data available on mavacamten efficacy within subsets of patients with non-obstructive HCM, researchers have designed the next phase of study on this select group, said Stephen Heitner, MD, director of Clinical Trials and director of the Hypertrophic Cardiomyopathy Center at the Oregon Health and Science University.
Based off the rich data available on mavacamten efficacy within subsets of patients with non-obstructive HCM, researchers have designed the next phase of study on this select group, said Stephen Heitner, MD, director of Clinical Trials and director of the Hypertrophic Cardiomyopathy Center at the Oregon Health and Science University.
Transcript
Can you discuss the results from MAVERICK-HCM? How will the insights from this study drive the next phase of research in non-obstructive HCM?
MAVERICK—we’re super excited to have finished. That’s looking at, I think there were 59 patients in this placebo-controlled multi-site study, looking at the impact of mavacamten in patients with non-obstructive HCM. You know this is a very ... challenging group of patients. What we have seen–you know this is a very high-level result–is firstly, that the NT-proBNP, which is a measure of left ventricular filling–a lot of these patients have heart failure with preserved ejection fraction as a result of hypertrophic cardiomyopathy. So, their NT-proBNPs was significantly reduced after 16 weeks of mavacamten therapy, which is incredible. What we’re doing right now is kind of going through the very rich data that we have from that to look at where mavacamten will be most useful. So, which subset of those patients mavacamten will be applicable for. Based on that, we’re going to be designing the next phase of study, which is the phase 3 in non-obstructive HCM patients to better inform and hopefully show that this is an effective therapy in these individuals.
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