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Dr Lee Schwartzberg Discusses Immunotherapy Approvals in TNBC
Lee Schwartzberg, MD, FACP, chief medical director of West Cancer Center and chief medical officer of OneOncology, discusses the approvals of pembrolizumab and sacituzumab govitecan for patients with triple-negative breast cancer.
Transcript
The FDA this year handed approvals to pembrolizumab and sacituzumab govitecan for the treatment of triple-negative breast cancer. What have the implications been for patients based on these approvals?
We’re excited about having new options for patients with metastatic triple-negative breast cancer. Sacituzumab govitecan has proven to be effective in a substantial number of triple-negative breast cancer patients and it’s now improved in the third line and beyond setting, and my experience with it has been very favorable. We do see some neutropenia associated with it and managing that we had to get comfortable with, but the efficacy of the drug is substantial and it’s clearly a new component to our armamentarium of treating metastatic triple-negative breast cancer.
We’re also excited about now having KEYTRUDA in combination with chemotherapy for patients that express a CPS score of greater than 10%, where the progression-free survival was improved in that setting, and we’re able to use a number of different chemotherapy pairings with KEYTRUDA, which showed benefit. So, that gives us another option of a combination therapy in the roughly 40% or so of patients that do express PD-L1 in the metastatic first-line triple-negative breast cancer setting.
Bias Reduction, Better Access Key to COVID-19 Equity Gains
April 14th 2025Interventions that target enhancing health care equity among communities disproportionately affected by the COVID-19 pandemic can be improved by including comprehensive needs assessments at the patient, provider, and health system levels.
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The Importance of Examining and Preventing Atrial Fibrillation
August 29th 2023At this year’s American Society for Preventive Cardiology Congress on CVD Prevention, Emelia J. Benjamin, MD, ScM, delivered the Honorary Fellow Award Lecture, “The Imperative to Focus on the Prevention of Atrial Fibrillation,” as the recipient of this year’s Honorary Fellow of the American Society for Preventive Cardiology award.
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Promoting Equity in Public Health: Policy, Investment, and Community Engagement Solutions
June 28th 2022On this episode of Managed Care Cast, we speak with Georges C. Benjamin, MD, executive director of the American Public Health Association, on the core takeaways of his keynote session at AHIP 2022 on public health policy and other solutions to promote equitable health and well-being.
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Managing Skin Conditions: Highlighting Ruxolitinib Cream, Phototherapy Efficacy and Cost
April 8th 2025Research presented at the 2025 Academy of Managed Care Pharmacy annual meeting analyzed real-world treatment outcomes for dermatologic conditions, specifically highlighting the efficacy of ruxolitinib cream for atopic dermatitis and the potential for phototherapy to delay costly biologic initiation.
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