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Dr David Snyder Outlines Use of Ruxolitinib After Approval of Fedratinib
After the approval of fedratinib, familiarity may keep people using ruxolitinib to treat myelofibrosis or polycythemia vera, but it’s good to know there is a back-up if needed for patients who don’t respond adequately, said David Snyder, MD, associate chair of the Department of Hematology & Hematopoietic Cell Transplantation at City of Hope.
After the approval of fedratinib, familiarity may keep people using ruxolitinib to treat myelofibrosis or polycythemia vera, but it’s good to know there is a back-up if needed for patients who don’t respond adequately, said David Snyder, MD, associate chair of the Department of Hematology & Hematopoietic Cell Transplantation at City of Hope.
How are you using ruxolitinib in light of the recent approval of fedratinib?
So, fedratinib was just approved as first line and as second line for salvage after ruxolitinib, so I have to say that since fedratinib was just approved, I don’t have much direct experience using it. So, from what I understand the toxicity profiles are fairly similar in terms of risk of myelosuppression. Fedratinib may have more in the way of [gastrointestinal] toxicity. So, I certainly have more familiarity with ruxolitinib, and I would tend maybe to go to that drug as first-line choice, but certainly there are many patients who either don’t respond adequately to ruxolitinib or do respond, but start to break through, and it’s good to know that there’s an option for those patients as well.
And, I’m always thinking about “Well, is this patient potentially a transplant candidate, and if so, it would be good to treat them with a JAK inhibitor to which they’re responding to help reduce their spleen size, control their systemic symptoms, improve their performance status,” which we think would help improve their outcomes, ultimately, after transplant.
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April 11th 2025Orca-T showed lower rates of graft-vs-host disease or infection compared with allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome (MDS) or acute leukemias in the Precision-T trial, Caspian Oliai, MD, MS, UCLA Bone Marrow Transplantation Stem Cell Processing Center, said.
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Personalized Care Key as Tirzepatide Use Expands Rapidly
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What the Updated Telephone Consumer Protection Act Rules Mean for Health Care Messaging
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Navigating Sport-Related Neurospine Injuries, Surgery, and Managed Care
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Bridging Education Gaps in Treatment for Scarring Alopecia With Innovative Approaches
March 28th 2025Crystal Aguh, MD, FAAD, Johns Hopkins School of Medicine faculty, highlights the critical need for comprehensive education on hair loss across diverse hair types, stressing the importance of understanding inflammatory pathways for developing targeted therapies.
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Dermatologists Advocating for Inclusive Hair Loss Research and Treatment in the African Diaspora
March 26th 2025Crystal Aguh, MD, FAAD, Johns Hopkins School of Medicine faculty, advocates for increased funding and education to address hair loss disparities within the African diaspora, emphasizing the need for culturally sensitive treatment and research.
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