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CUDC-101 Provides Encouraging Results in Phase 1 Head and Neck Cancer
The drug targets multiple proteins that are overexpressed in head and neck cancer, the study published in Clinical Cancer Research says.
Head and neck cancer is among the few solid tumors whose incidence is increasing in the United States. and outcomes have been slow to improve. Results of a phase 1 trial of the drug CUDC-101 with radiation and chemotherapy were reported by the University of Colorado Cancer Center and 6 other US cancer centers in the journal Clinical Cancer Research.
CUDC-101, currently being developed by Curis, Inc, works by inhibiting two growth factors and an enzyme that effects DNA expression—EGFR, Her2 and HDAC—all of which are overexpressed in many cancers, including the target of this trial: the common type of especially aggressive head and neck cancer that is not caused by the human papilloma virus (HPV-) but rather by tobacco or alcohol.
Link to the complete report in ScienceDaily:
Exploring Racial, Ethnic Disparities in Cancer Care Prior Authorization Decisions
October 24th 2024On this episode of Managed Care Cast, we're talking with the author of a study published in the October 2024 issue of The American Journal of Managed Care® that explored prior authorization decisions in cancer care by race and ethnicity for commercially insured patients.
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NCCN Data Find Racial, Socioeconomic Disparities in Quality of Care for Metastatic Pancreatic Cancer
April 9th 2025New data from the National Comprehensive Cancer Network (NCCN) reveal that socially vulnerable and minority patients with metastatic pancreatic cancer are less likely to receive recommended treatments and achieve longer survival.
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Examining Low-Value Cancer Care Trends Amidst the COVID-19 Pandemic
April 25th 2024On this episode of Managed Care Cast, we're talking with the authors of a study published in the April 2024 issue of The American Journal of Managed Care® about their findings on the rates of low-value cancer care services throughout the COVID-19 pandemic.
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