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CTCs and LDH: Surrogates for Survival in Advanced Prostate Cancer
The trial, whose results were published in the Journal of Clinical Oncology, found that circulating tumor cells and lactose dehydrogenase are ideal surrogates to predict overall survival in patients with advanced prostate cancer.
A biomarker panel of circulating tumor cell count plus lactate dehydrogenase level met criteria as a surrogate for overall survival in individual patients with castration-resistant prostate cancer, according to research published online March 23 in the Journal of Clinical Oncology.
Recent progress in prostate cancer therapy has created the need for reliable post-treatment outcome measures that are surrogates for survival to guide patient management and to aid in the regulatory approval process. Investigators sought to identify an efficacy-response surrogate, to be confirmed in future trials, within the phase III clinical trial for abiraterone acetate plus prednisone vs. prednisone alone for patients with castration-resistant prostate cancer.
“Such a surrogate would shorten drug development times and eliminate the potential confounding effects of post protocol therapy on survival,” wrote Dr Howard I. Scher, head of the genitourinary oncology service at the Sidney Kimmel Center for Urologic and Prostate Cancers at Memorial Sloan Kettering Cancer Center, New York, and associates.
Link to the report on Oncology Practice:
Exploring Racial, Ethnic Disparities in Cancer Care Prior Authorization Decisions
October 24th 2024On this episode of Managed Care Cast, we're talking with the author of a study published in the October 2024 issue of The American Journal of Managed Care® that explored prior authorization decisions in cancer care by race and ethnicity for commercially insured patients.
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Examining Low-Value Cancer Care Trends Amidst the COVID-19 Pandemic
April 25th 2024On this episode of Managed Care Cast, we're talking with the authors of a study published in the April 2024 issue of The American Journal of Managed Care® about their findings on the rates of low-value cancer care services throughout the COVID-19 pandemic.
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