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c-Met Signals to Intracellular Rac to Promote Breast Cancer Metastasis
A research article published in Nature Communications identifies a new mechanism of breast cancer metastasis.
Scientists at Queen Mary University of London (QMUL) have uncovered a new mechanism which makes breast cancer cells move and invade the body, a discovery which could shed light on how to treat particularly aggressive forms of breast cancer and stop it spreading and recurring.
Nature Communications
The study — published in the journal and led by QMUL's Barts Cancer Institute — investigated the role of a molecule called 'c-Met' which is present in almost a third of breast cancer patients and is known to make breast cancer cells move, and therefore spread, around the body. This process is known as metastasis and is a major cause of treatment failure and cancer death.
When looking at aggressive breast cancer cells, the researchers found that c-Met acted differently to normal and 'switched on' another important molecule (known as 'Rac'), from a specific location inside the cell, instead of from the cell surface, as previously thought. This signalling inside the cell is necessary to trigger the cancer cells movement.
Source: MedicalXpress
Exploring Racial, Ethnic Disparities in Cancer Care Prior Authorization Decisions
October 24th 2024On this episode of Managed Care Cast, we're talking with the author of a study published in the October 2024 issue of The American Journal of Managed Care® that explored prior authorization decisions in cancer care by race and ethnicity for commercially insured patients.
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Physician-Pharmacy Integration in Cancer Care: Pillars of Medically Integrated Pharmacy
December 16th 2025The foundation of medically integrated pharmacy includes 7 critical pillars. This commentary focuses on the benefits of 3 of those pillars: abandonment, adherence, and access/affordability.
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