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c-Met Signals to Intracellular Rac to Promote Breast Cancer Metastasis
A research article published in Nature Communications identifies a new mechanism of breast cancer metastasis.
Scientists at Queen Mary University of London (QMUL) have uncovered a new mechanism which makes breast cancer cells move and invade the body, a discovery which could shed light on how to treat particularly aggressive forms of breast cancer and stop it spreading and recurring.
Nature Communications
The study — published in the journal and led by QMUL's Barts Cancer Institute — investigated the role of a molecule called 'c-Met' which is present in almost a third of breast cancer patients and is known to make breast cancer cells move, and therefore spread, around the body. This process is known as metastasis and is a major cause of treatment failure and cancer death.
When looking at aggressive breast cancer cells, the researchers found that c-Met acted differently to normal and 'switched on' another important molecule (known as 'Rac'), from a specific location inside the cell, instead of from the cell surface, as previously thought. This signalling inside the cell is necessary to trigger the cancer cells movement.
Source: MedicalXpress
Exploring Racial, Ethnic Disparities in Cancer Care Prior Authorization Decisions
October 24th 2024On this episode of Managed Care Cast, we're talking with the author of a study published in the October 2024 issue of The American Journal of Managed Care® that explored prior authorization decisions in cancer care by race and ethnicity for commercially insured patients.
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Uniting to Support Patients With Cancer Beyond Treatment
November 17th 2024Kasey Bond, MPH, of Perlmutter Cancer Center at NYU Langone Health, speaks to why it’s vital to keep patients at the center of all strategic partnerships between academic institutions and community-based oncology practices.
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Examining Low-Value Cancer Care Trends Amidst the COVID-19 Pandemic
April 25th 2024On this episode of Managed Care Cast, we're talking with the authors of a study published in the April 2024 issue of The American Journal of Managed Care® about their findings on the rates of low-value cancer care services throughout the COVID-19 pandemic.
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Bridging Cancer Care Gaps and Overcoming Medical Mistrust
November 13th 2024In this clip from our interview with Oscar B. Lahoud, MD, cochair of our Institute for Value-Based Medicine® evening hosted with NYU Langone Health, he addressed medical mistrust in underrepresented communities.
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How English- and Spanish-Preferring Patients With Cancer Decide on Emergency Care
November 13th 2024Care delivery innovations to help patients with cancer avoid emergency department visits are underused. The authors interviewed English- and Spanish-preferring patients at 2 diverse health systems to understand why.
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