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Bevacizumab Proves Effective in Combination With Chemotherapy in Platinum-Resistant Ovarian Cancer
The AURELIA trial comparing the efficacy of bevacizumab plus chemotherapy, versus chemotherapy alone, presented encouraging results in platinum-resistant ovarian cancer patients.
An editorial published in the latest issue of the Journal of Clinical Oncology highlights the encouraging results reported by the AURELIA trial, a randomized trial comparing the effectiveness of chemotherapy (investigator’s choice of once-per-week paclitaxel, pegylated liposomal doxorubicin, or topotecan) combined with bevacizumab in recurrent platinum-resistant ovarian cancer. A companion article in the same issue reports patient-related outcomes (PROs) in AURELIA, evaluating abdominal/GI PROs in the patients.
Reflecting the results reported by previous trials that studied bevacizumab (GOG, ICON7 and OCEANS), AURELIA observed a statistically significant benefit in progression-free survival (PFS) by including bevacizumab in the chemotherapy regimen. A significant improvement (3.3 months) in median PFS was observed, with the patients in the bevacizumab plus chemotherapy arm presenting a median survival of 6.7 months (hazard ratio, 0.48; 95% confidence interval 0.38 to 0.60; P <0.001) compared to a median survival of 3.3 months observed in patients receiving chemotherapy alone. Further, similar to the OCEANS trial, overall response rate (OSS) significantly improved from 11.8% to 27.3% (P = 0.001) in the bevacizumab plus chemotherapy arm in the AURELIA trial, as assessed by the RECIST criteria.
Read the complete editorial here: http://bit.ly/1fevs2JSource: Journal of Clinical Oncology; Published online March 17, 2014
Exploring Racial, Ethnic Disparities in Cancer Care Prior Authorization Decisions
October 24th 2024On this episode of Managed Care Cast, we're talking with the author of a study published in the October 2024 issue of The American Journal of Managed Care® that explored prior authorization decisions in cancer care by race and ethnicity for commercially insured patients.
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Texas Oncology to Roll Out Canopy for ePROs After Head-to-Head Pilot
March 18th 2025Debra Patt, MD, PhD, MBA, executive vice president of Public Policy and Strategy for Texas Oncology, said the practice received positive feedback from nurses and patients during a pilot that concluded in February.
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Examining Low-Value Cancer Care Trends Amidst the COVID-19 Pandemic
April 25th 2024On this episode of Managed Care Cast, we're talking with the authors of a study published in the April 2024 issue of The American Journal of Managed Care® about their findings on the rates of low-value cancer care services throughout the COVID-19 pandemic.
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