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Transforming Pulmonary Arterial Hypertension Management: Bridging Clinical Practice, Innovative Therapies, and Economic Impact
Ryan Haumschild, PharmD, MBA, MS; Sandeep Sahay, MD, FCCP; Murali Chakinala, MD, FCCP, and Marius M. Hoeper, MD, discuss how pulmonary arterial hypertension management has evolved with new therapeutic pathways like sotatercept offering reverse remodeling capabilities, requiring individualized treatment approaches that balance disease severity, patient preferences, and economic considerations while emphasizing early diagnosis and aggressive upfront combination therapy to achieve disease remission and reduce long-term healthcare costs.
EP. 1: Pathophysiology of Pulmonary Arterial Hypertension
Panelists discuss how the pathophysiology of pulmonary arterial hypertension involves complex mechanisms across multiple genetic and treatment pathways, with over 20 identified genes and four major therapeutic targets including nitric oxide, endothelin, prostacyclin, and activin signaling inhibition.
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EP. 2: Differential Diagnosis of Pulmonary Arterial Hypertension
Panelists discuss how pulmonary arterial hypertension diagnosis requires comprehensive evaluation including right heart catheterization to confirm hemodynamic criteria, with normal mean PA pressure being ≤20 mmHg and the need to rule out other causes of pulmonary hypertension.
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